|
1986 |
- HIV testing of stored specimens
- Study expanded to include neurological aspects
|
|
1987 |
- Flow cytometry methods standardized
- Risky sex linked to HIV seropositivity
- Low CD4 closely linked with progression to clinical AIDS
|
|
1988 |
- WHO guidelines for lack of cognitive impairment in
asymptomatic individuals
|
|
1989 |
- CD4<200 and thrush predicts PCP
- PHS guidelines for PCP prophylaxis
- Juxta-analysis of prevalent and incident cohorts
- Resistance to infection in high risk seronegative men
|
|
1990 |
- Description of incidence of KS
- Serologic markers add to prediction of AIDS
|
|
1991 |
- Incidence of HIV by calendar, place, age and ethnicity
- Confirmation of efficacy of Zidovudine and PCP prophylaxis
|
|
1992 |
- Role of brain cytokines on AIDS dementia
|
|
1993 |
- Changes in the spectrum of AIDS and survival due to PCP
prophylaxis and Zidovudine
- Elevated levels of a subset of CD8 cells add to prognostic
value of CD4 cell counts
|
|
1995 |
- Long term non-progressors are characterized
- Loss of T-cell homeostasis predicts development of disease
|
|
1996 |
- Role of genetic markers (HLA and CCR5) on HIV
infection and disease progression
- Incubation of AIDS follows a lognormal distribution
- Old age confirmed as risk factor for short AIDS incubation
|
|
1997 |
- Viral load quantified in archived plasma specimens
|
|
1998 |
- NIH guidelines for use of potent ART
- Effectiveness of potent antiretroviral therapy: AIDS-free
extended by 1.63
- Methods to detect inflection points developed
|
|
1999 |
- Dramatic effect of potent ART on KS
- 80% of AIDS-free HIV positive active participants receiving
antiretroviral therapy. Most (80%) receiving potent ART
- Reduce risk of AIDS lymphoma in individuals heterozygous
for CCR5
- Comparison of prognostic value of T-lymphocyte activation
with viral load and chemokine receptors
- Viability of samples stored in National Repository shown
|
|
2000 |
- Across cohorts (MACS & WIHS) comparison of HIV RNA
- Interaction of HIV and HHV8 on incidence of KS
- Natural history of HIV viremia after seroconversion
- Efficacy, individual effectiveness and population
effectiveness of therapies
|
|
2001 |
- Effectiveness of HAART shown to extend to both primary and
secondary opportunistic infections
- HIV infection preceding infection with HHV-8 increases
the risk for Kaposi's Sarcoma
- Thrush and fever do provide a measures of immune
competence in the era of HAART
- Extension of methods to assess effectiveness in prevalent
cohorts
- Self-reported adherence measure validated by HIV RNA levels
and host characteristics (race, income, use of health
care system) as well as therapy factors found to be
independent determinants of full adherence
|
|
2002 |
- Effect of coinfection with HIV and HBV in the HAART era
- Lower CD4 cell counts and age at HAART initiation and risk
of CD4 response predicted AIDS after HAART. AIDS risk
post-HAART in men with <200 CD4 cells was similar to
that of men with 300 more cells in the pre-HAART era
- Genetic influence of RANTES and intervention between KIR
and HLA on progression to AIDS
- Attitudes towards highly active antiretroviral therapy are
associated with sexual risk taking
- Immunologic and virologic response to HAART was
characterized
|
|
2003 |
- Effect of deferring HAART while accouting for lead-time
bias
- Lipid level changes associated with HIV infection and use
of HAART
- Prognostic effect of changes in total lymphocytes and
hemoglobin levels
- MCP haplotype effect on HIV infection
- Graphical methods to better display 3-dimensional data
|
|
2004 |
- Dual HIV infection associated with rapid disease
progression
- Preventive fraction of AIDS in pre-HAART era due to
genetic polymorphisms
- Persistent GBV-C infection influence on survival
- Predictors of changing adherence to antiretroviral
therapies
|
