The Multicenter AIDS Cohort Study (MACS) is an ongoing prospective study of the natural and treated histories of HIV-1 infection in homosexual and bisexual men conducted by sites located in Baltimore, Chicago, Pittsburgh and Los Angeles. A total of 6,972 men have been enrolled. From April 1984 through March 1985, 4954 men were enrolled; an additional 668 men were enrolled from April 1987 through September 1991. A third enrollment of 1350 men took place between October 2001 and August 2003. This third cohort augments research efforts in the long term benefits and adverse effects of therapy.
Highlights of MACS/WIHS
Protocol and Cohorts
A searchable database of all MACS publications.
MACS Scientific Contributions
Having published over 1300 publications, the MACS has made significant contributions to understanding the science of HIV, the AIDS epidemic, and the effects of therapy. Many of these MACS publications have guided Public Health Policy.
Contact information for MACS affiliated investigators and staff, ExecutiveCommittee members, and a listing of Working Groups and their members.
A compendium of slides to illustrate the MACS study design and provide a description of the cohort. Many of the slides include a reference. For more detail, please direct your attention to this reference in the MACS Archives.
- Administrative Forms
Administrative forms help data management and coordination: data transferred between sites and the data center; proposed research using MACS data and specimens; participants consent for use of specimens.
- Data Collection Forms
Instruments used to collect data from the participants at each visit (including baseline and follow-up) and continuously to capture specific events (including an AIDS, cancer or other reportable diagnosis, death or seroconversion).
NIH AIDS Research and Reference Reagent Program
To request lymphoblastic cell lines, the NIH AIDS Research and Reference Reagent Program requires all investigators to be registered prior to receiving samples.
MACS Manuscript Templates
Includes the following:
- HAART definition
- MACS acknowledgement
- Alternative acknowledgement
- Links to author's instructions for specific journals
MACS Public Data Set
MACS data for public use permits access to the MACS data to a wide range of scientists and
in particular to statisticians and mathematical modelers who would like to use these data to illustrate their different methodological approaches.
MACS Study Administration
Restricted page, login required.
Restricted page, login required.
The MACS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the National Cancer Institute (NCI) [U01-AI35039, U01-AI35040; U01-AI35041; U01-AI35042; and UM1-AI35043], the National Institute on Drug Abuse (NIDA), and the National Institute of Mental Health (NIMH). Targeted supplemental funding for specific projects was also provided by the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute on Deafness and Communication Disorders (NIDCD). MACS data collection is also supported by UL1-TR001079 (JHU ICTR) from the National Center for Advancing Translational Sciences (NCATS) a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research.