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MACS History The Multicenter AIDS Cohort Study (MACS) is an ongoing prospective study of the natural and treated histories of HIV-1 infection in homosexual and bisexual men conducted by sites located in Baltimore, Chicago, Pittsburgh and Los Angeles. A total of 6,972 men have been enrolled. From April 1984 through March 1985, 4954 men were enrolled; an additional 668 men were enrolled from April 1987 through September 1991. A third enrollment of 1350 men took place between October 2001 and August 2003. This third cohort augments research efforts in the long term benefits and adverse effects of therapy. Highlights of MACS/WIHS Protocol and Cohorts MACS Archives A searchable database of all MACS publications. MACS Scientific Contributions Having published over 1100 publications, the MACS has made significant contributions to understanding the science of HIV, the AIDS epidemic, and the effects of therapy. Many of these MACS publications have guided Public Health Policy. MACS Directory Contact information for MACS affiliated investigators and staff, ExecutiveCommittee members, and a listing of Working Groups and their members. MACS Dossier A compendium of slides to illustrate the MACS study design and provide a description of the cohort. Many of the slides include a reference. For more detail, please direct your attention to this reference in the MACS Archives. MACS Sponsorship National Institute of Allergy and Infectious Diseases(NIAID) National Cancer Institute(NCI) NCI Office of HIV and AIDS Malignancy (OHAM) MACS Forms Administrative Forms Administrative forms help data management and coordination: data transferred between sites and the data center; proposed research using MACS data and specimens; participants consent for use of specimens. Data Collection Forms Instruments used to collect data from the participants at each visit (including baseline and follow-up) and continuously to capture specific events (including an AIDS, cancer or other reportable diagnosis, death or seroconversion). NIH AIDS Research and Reference Reagent Program To request lymphoblastic cell lines, the NIH AIDS Research and Reference Reagent Program requires all investigators to be registered prior to receiving samples. MACS Manuscript Templates Includes the following: HAART definition MACS acknowledgement Alternative acknowledgement Links to author's instructions for specific journals MACS Public Data Set MACS data for public use permits access to the MACS data to a wide range of scientists and in particular to statisticians and mathematical modelers who would like to use these data to illustrate their different methodological approaches. MACS Study Administration Restricted page, login required. MACS Forum Restricted page, login required. Related Links AIDSinfo (A Service of The U.S. Department of Health and Human Services) The HIV Protease Structural Database (has 3-D structures of HIV -1 and 2; and SIV proteases etc. It's intended to help researchers, educators and students. ) World AIDS Day Web Page HIV/AIDS Awareness Days Web Page MACS Data Management System (MDMS) This project has been funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute: U01-AI-35042, 5-M01-RR-00052 (GCRC),U01-AI-35043, U01-AI-37984, U01-AI-35039, U01-AI-35040, U01-AI-37613,U01-AI-35041. This page was last updated April 2010.