Manuscript Templates HAART definition: The following is a paragraph defining HAART for the "Methods Section" of MACS publications (as of March 31, 2007). The percentages are based on total HIV+ person-visits with available therapy data from July 1995 to March 2007. The first paragraph may be used for papers that are related to HAART. The definition of HAART was guided by the DHHS/Kaiser Panel [DHHS/Kaiser 2006] guidelines and defined as: (a) two or more NRTIs in combination with at least one PI or one NNRTI (89% of observations classified as HAART); (b) one NRTI in combination with at least one PI and at least one NNRTI (5%); (c) a regimen containing ritonavir and saquinavir in combination with one NRTI and no NNRTIs (1%); and (d) an abacavir or tenofovir containing regimen of three or more NRTIs in the absence of both PIs and NNRTIs (5%), except for the three-NRTI regimens consisting of: abacavir + tenofovir + lamivudine OR didanosine + tenofovir + lamivudine. Combinations of zidovudine (AZT) and stavudine (d4T) with either a PI or NNRTI were not considered HAART. The most frequent case of monotherapy was of one NRTI (72%). Of the other monotherapy cases, taking only PIs accounted for 23%; while taking only NNRTIs accounted for 5%. All other ART regimens were classified as combination therapy. The three most frequent cases of combination therapy were: (a) only two NRTIs (59%); (b) at least one PI and at least one NNRTI in the absence of NRTI (10%); and (c) one NRTI and one PI in the absence of NNRTI (8%) Reference: DHHS/Henry J. Kaiser Family Foundation Panel on Clinical Practices for the Treatment of HIV infection. Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. May 2006 revision. Available at: http://aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL05042006050.pdf.   Definitions: HAART = highly active antiretroviral therapy NNRTI = non-nucleoside reverse transcriptase inhibitor NRTI = nucleoside or nucleotide reverse transcriptase inhibitor PI = protease inhibitor MACS acknowledgment: The Multicenter AIDS Cohort Study (MACS) includes the following:   Baltimore: The Johns Hopkins University Bloomberg School of Public Health: Joseph B. Margolick (Principal Investigator), Haroutune Armenian, Barbara Crain, Adrian Dobs, Homayoon Farzadegan, Joel Gallant, John Hylton, Lisette Johnson, Shenghan Lai, Ned Sacktor, Ola Selnes, James Shepard, Chloe Thio.   Chicago: Howard Brown Health Center, Feinberg School of Medicine, Northwestern University, and Cook County Bureau of Health Services: John P. Phair (Principal Investigator), Joan S. Chmiel (Co-Principal Investigator), Sheila Badri, Bruce Cohen, Craig Conover, Maurice O'Gorman, David Ostrow, Frank Palella, Daina Variakojis, Steven M. Wolinsky.   Los Angeles: University of California, UCLA Schools of Public Health and Medicine: Roger Detels (Principal Investigator), Barbara R. Visscher (Co-Principal Investigator), Aaron Aronow, Robert Bolan, Elizabeth Breen, Anthony Butch, Thomas Coates, Rita Effros, John Fahey, Beth Jamieson, Otoniel Martínez-Maza, Eric N. Miller, John Oishi, Paul Satz, Harry Vinters, Dorothy Wiley, Mallory Witt, Otto Yang, Stephen Young, Zuo Feng Zhang.   Pittsburgh: University of Pittsburgh, Graduate School of Public Health: Charles R. Rinaldo (Principal Investigator), Lawrence Kingsley (Co-Principal Investigator), James T. Becker, Robert W. Evans, John Mellors, Sharon Riddler, Anthony Silvestre.   Data Coordinating Center: The Johns Hopkins University Bloomberg School of Public Health: Lisa P. Jacobson (Principal Investigator), Alvaro Muñoz (Co-Principal Investigator), Stephen R. Cole, Christopher Cox, Gypsyamber D'Souza, Stephen J. Gange, Janet Schollenberger, Eric C. Seaberg, Sol Su.   NIH: National Institute of Allergy and Infectious Diseases: Robin E. Huebner; National Cancer Institute: Geraldina Dominguez; National Heart, Lung and Blood Institute: Cheryl McDonald.  UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041.   Website located at http://www.statepi.jhsph.edu/macs/macs.html. Suggested alternative acknowledgment for manuscripts when MACS data have been used: Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS) with centers (Principal Investigators) at The Johns Hopkins University Bloomberg School of Public Health (Joseph B. Margolick, Lisa Jacobson), Howard Brown Health Center and Northwestern University Medical School (John Phair), University of California, Los Angeles (Roger Detels), and University of Pittsburgh (Charles Rinaldo).   The MACS is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute and the National Heart, Lung and Blood Institute.   UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041.  Website located at http://www.statepi.jhsph.edu/macs/macs.html. Links to author's instructions for specific journals -   AIDS -   AIDS Research and Human Retroviruses -   American Journal of Epidemiology -   Annals of Internal Medicine -   JAMA -   Journal of Acquired Immune Deficiency Syndromes -   Journal of Infectious Diseases -   Lancet -   New England Journal of Medicine This page was last updated January 2008.